Manufacturer
HEALOL PHARMACEUTICALS SDN. BHD.
Contents
Amlodipine besilate
Indication
1st-line treatment of HTN & myocardial ischaemia. Monotherapy or in combination w/ other antianginal drugs in angina which is refractory to nitrates &/or adequate doses of β-blockers.
Instruction
May be taken with or without food.
Drug interaction
It has been safely administered with thiazide diuretics, beta-adrenoceptor blocking drugs, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual glyceryl trinitrate, non-steroidal anti-inflammatory drugs, antibiotics and oral hypoglycemic agents.
Co-administration of Amlodipine Besilate with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers. Co-administration of cimetidine did not alter the pharmacokinetics of amlodipine. In healthy volunteers, co-administration of Amlodipine Besilate did not significantly alter the effect of warfarin on prothrombin time. The introduction of Amlodipine Besilate is not likely to result in the need for modification of an established warfarin regimen. In vitro data from studies with human plasma indicate that amlodipine has no effect on protein binding of digoxin, phenytoin, warfarin or indomethacin.
HEALOL PHARMACEUTICALS SDN. BHD.
Contents
Amlodipine besilate
Indication
1st-line treatment of HTN & myocardial ischaemia. Monotherapy or in combination w/ other antianginal drugs in angina which is refractory to nitrates &/or adequate doses of β-blockers.
Instruction
May be taken with or without food.
Drug interaction
It has been safely administered with thiazide diuretics, beta-adrenoceptor blocking drugs, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual glyceryl trinitrate, non-steroidal anti-inflammatory drugs, antibiotics and oral hypoglycemic agents.
Co-administration of Amlodipine Besilate with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers. Co-administration of cimetidine did not alter the pharmacokinetics of amlodipine. In healthy volunteers, co-administration of Amlodipine Besilate did not significantly alter the effect of warfarin on prothrombin time. The introduction of Amlodipine Besilate is not likely to result in the need for modification of an established warfarin regimen. In vitro data from studies with human plasma indicate that amlodipine has no effect on protein binding of digoxin, phenytoin, warfarin or indomethacin.
Inquiry - Name Kardam 10 (Amlodipine Besilate Tablets 10mg)