Manufacturer
Inventia Healthcare Limited
Contents
Per 2/500 mg SR tab Glimepiride 2 mg, metformin HCl 500 mg
Indication
Adjunct to diet & exercise in type 2 DM when glimepiride or metformin monotherapy does not result in adequate glycemic control. Replacement of combination therapy of glimepiride & metformin.
Instruction
Should be taken with food: Take immediately before or during breakfast, or the 1st main meal of the day. Swallow whole do not chew/crush.
Drug interaction
CYP2C9 inducers/inhibitors. Effect may be potentiated by insulin & other oral antidiabetics, ACE inhibitors, anabolic steroids, male sex hormones, chloramphenicol, coumarin derivatives, cyclophosphamide, disopyramide, fenfluramine, fenyramidol, fibrates, fluoxetine, guanethidine, ifosfamide; MAOIs, miconazole, fluconazole, para-aminosalicylic acid, pentoxifylline, phenylbutazone, azapropazone, oxyphenbutazone, probenecid, quinolones, salicylates, sulfinpyrazone, clarithromycin, sulfonamide antibiotics, tetracyclines, tritoqualine, trofosfamide. Effect may be weakened by acetazolamide, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine, other sympathomimetics, glucagon, laxatives, nicotinic acid (in high doses), oestrogens, progestogens, phenothiazines, phenytoin, rifampicin, thyroid hormones. H2-receptor agonists, β-blockers, clonidine, reserpine, alcohol may potentiate/weaken effect. Glucocorticoids, salbutamol, formoterol, diuretics, ACE inhibitors.
Inventia Healthcare Limited
Contents
Per 2/500 mg SR tab Glimepiride 2 mg, metformin HCl 500 mg
Indication
Adjunct to diet & exercise in type 2 DM when glimepiride or metformin monotherapy does not result in adequate glycemic control. Replacement of combination therapy of glimepiride & metformin.
Instruction
Should be taken with food: Take immediately before or during breakfast, or the 1st main meal of the day. Swallow whole do not chew/crush.
Drug interaction
CYP2C9 inducers/inhibitors. Effect may be potentiated by insulin & other oral antidiabetics, ACE inhibitors, anabolic steroids, male sex hormones, chloramphenicol, coumarin derivatives, cyclophosphamide, disopyramide, fenfluramine, fenyramidol, fibrates, fluoxetine, guanethidine, ifosfamide; MAOIs, miconazole, fluconazole, para-aminosalicylic acid, pentoxifylline, phenylbutazone, azapropazone, oxyphenbutazone, probenecid, quinolones, salicylates, sulfinpyrazone, clarithromycin, sulfonamide antibiotics, tetracyclines, tritoqualine, trofosfamide. Effect may be weakened by acetazolamide, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine, other sympathomimetics, glucagon, laxatives, nicotinic acid (in high doses), oestrogens, progestogens, phenothiazines, phenytoin, rifampicin, thyroid hormones. H2-receptor agonists, β-blockers, clonidine, reserpine, alcohol may potentiate/weaken effect. Glucocorticoids, salbutamol, formoterol, diuretics, ACE inhibitors.
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